Theresa M. Lyons, MS, MS, PhD

Education

• Yale University 2004 - 2006 Ph.D. in Computational Chemisty.
  • Adviser: Dr. William L. Jorgensen
• Yale University 2002 - 2004 M.S. in Chemistry
  • Adviser: Dr. William L. Jorgensen
• St. John's University 2000 - 2002 M.S. in Synthetic Organic Chemistry, GPA 3.9
  • Adviser: Dr. Victor O. Cesare
• Hobart and William Smith Colleges 1996 - 2000 B.S. cum laude major: chemistry
  • Dean’s List 1997-2000, Girl Scout Brittenstool Scholarship 1996-2000, Inducted into Phi Lamda Upsilon and Sigma Xi 2000, Chemistry Achievement Award of the Rochester Section of the American Chemical Society 2000, Helen Heath Scholar 1996-1997, American Chemical Society certified major in chemistry.

Experience

• 81qd 2007 - present Medical Strategist.
  • I am the lead scientific person for new business development, sales, procurement, new business pitching, and proposal development. I work closely with marketing teams at various global pharmaceutical & healthcare companies consulting on drug life cycle management. I am an expert in identifying Key Opinion Leaders (KOLs), physician influence mapping, market research, sentiment analysis, and peer-to-peer teaching. I have experience working for clients in oncology and immunology.
• sanofi-aventis 2006 - 2007 Post-Doctoral Fellow.
  • I devised a scientific strategy to efficiently share metabolism data quickly between departments. I led a team to create a prototype corporate metabolism database in which I managed all aspects of the project from database design to presentation of the corporate metabolism database to Global Department heads. My research involved predicting the metabolism of small drug-like molecules by cytochrome P450 via atom fragment contribution. I analyzed vast amounts of data and determined trends correlating to chemical structure. Lastly, I formulated and tested models to predict metabolic sites of potential drugs

Publications

Lengyel, I.; Taldone, T.; Lyons, T.M.; Cesare, V.O. "Full Characterization, Thermal Decomposition, and Reactions of 1-(2-adamantyl)-3-(1-adamantyl)aziridin-2-one." Accepted by the Journal of Heterocyclic Chemistry

Barreiro, G.; Guimaraes, C. R. W.; Tubert-Brohman, I.; Lyons, T. M.; Tirado-Rives, J.; Jorgensen, W. L. "Search for Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase Using Chemical Similarity, Molecular Docking, and MM-GB/SA Scoring." J. Chem. Inf. Model. 47, 2416-2428 (2007)

Cesare, V.O.; Lyons, T.M.; Lengyel, I. "A High-Yielding Synthesis of a-Lactams (Aziridinones)." Synthesis, 12, 1716-1720 (2002).

Selected Presentations

T.M. Lyons, I. Tubert-Brohman, and W.L. Jorgensen “A Priori pKa predictions: Investigation of steric effects on the basicity of substituted pyridines via MC/FEP calculations” National ACS Meeting, New York, NY September 2003.

T.M. Lyons, I. Tubert-Brohman, and W.L. Jorgensen “A Priori pKa calculations and the Steric Effect on a Series of Substituted Pyridine Molecule” Yale University Biophysical Symposium, New Haven, CT May 2003

T.M. Lyons, V.O. Cesare, and I. Lengyel "A New Synthesis of a-Lactams (aziridinones).” National ACS Meeting Orlando, FL April 2002

T.M. Lyons and Carol Parish "Docking Studies Using the Low Mode Conformational Search Algorithm” National ACS Meeting San Francisco, CA March 2000

T.M. Lyons "Conformational Analysis of FDA Approved HIV Protease Inhibitors” Hobart and William Smith Colleges chapter Phi Beta Kappa Student Showcase Invited Talk Geneva, NY May 1999

T.M. Lyons and Carol Parish "Conformational Comparison of FDA Approved HIV Protease Inhibitors” National ACS Meeting Boston, MA August 1998.

Grants

NIH Biophysical Training Grant Recipient 2004 - 2005

Frederick W. Heyl Fellowship and Teaching Fellowship 2003 – 2004

Yale University and Teaching Fellowship 2002 - 2003

St. John's University Graduate Assistantship 2000 - 2002

Council on Undergraduate Research Summer Research Fellowship Summer 1999

Hobart and William Smith Colleges Provost Summer Fellowship Summer 1998

Teaching Experience

Spring 2004 Advanced Organic Chemistry - Yale University

Fall 2003 Organic Chemistry - Yale University

Spring 2003 and Fall 2002 General Chemistry Laboratory - Yale University

Spring 2002 Organic Chemistry Laboratory - St. John's University

Fall 2002 Organic Chemistry Laboratory - St. John's University

Spring 2001 Organic Chemistry Laboratory and General Chemistry Laboratory - St. John's University

Fall 2000 Organic Chemistry Laboratory and General Chemistry Laboratory - St. John's University