Personal web site of    

Theresa M. Lyons, MS, MS, PhD

Education

  • Yale University 2004 - 2006 Ph.D. in Computational Chemisty.
    • Adviser: Dr. William L. Jorgensen
  • Yale University 2002 - 2004 M.S. in Chemistry
    • Adviser: Dr. William L. Jorgensen
  • St. John's University 2000 - 2002 M.S. in Synthetic Organic Chemistry, GPA 3.9
    • Adviser: Dr. Victor O. Cesare
  • Hobart and William Smith Colleges 1996 - 2000 B.S. cum laude major: chemistry
    • Dean’s List 1997-2000, Girl Scout Brittenstool Scholarship 1996-2000, Inducted into Phi Lamda Upsilon and Sigma Xi 2000, Chemistry Achievement Award of the Rochester Section of the American Chemical Society 2000, Helen Heath Scholar 1996-1997, American Chemical Society certified major in chemistry.

Experience

  • Director, Business Strategy & Procurement

    Catholic Medical Mission Board 2010 - 2011

     
    • Strategic planning and development (USA/Latin America/Africa/Asia)
    • Negotiate and manage contractual agreements and interactions
    • Oversee the delivery of $300M of pharmaceuticals and medical supplies to Latin America, Africa, Asia
    • Improved internal supply chain via technology implementations
    • Partnerships in El Salvador, Haiti, Nicaragua, Peru
    • Implemented salesforce

  • Regional Alliance and Development Manager

    Multiple Myeloma Research Foundation 2008 - 2010

     
    • Responsible for the expansion of efficient and effective development programs to enhance cultivation and reinvestment of the MMRF's annual revenue budget of $22MM.
    • Establish relationships with top national hematology oncologists (heme-onc) KOLs as well as local oncologists.
    • Cultivate high net worth individuals to foster relationships resulting in financial donations. Oversee the generation of $3.8MM in revenue from major donors.
    • Planned and executed the MMRF’s Investors Summit, which involved identification of national myeloma Key Opinion Leaders (KOLs), speaker training of MMRF messaging, and management of event consultants while working closely with our marketing strategy and scientific communications team. Advocated to stream the Summit live over the internet to high net worth individuals and their medical advisors not in attendance. Raised $350k in revenue from Investors Summit.
    • Oversee $2.5MM in revenue generation from programs such as Online Giving, Planned Giving, Federal Campaigns, Annual Appeals, and Newsletters.
    • Created, managed, and executed online marketing strategy which resulted in a 29% increase in total 2008 online giving in comparison to 2007.
    • Gave sales/donor presentations to high-net worth individuals as a team and alone.
    • Participated in key external and internal scientific meetings.

  • Medical Strategist

    81qd 2007 - 2008

     
    • Team leader on business development and life cycle management for a strategic consulting company in the design of custom enterprise technology solutions.
    • Expert status in the process of identification of Key Opinion Leaders (KOLs) for breast cancer, colorectal cancer, growth hormones, renal cell carcinoma, chronic lymphocytic leukemia, glioblastoma multiforme, and lupus.
    • Managed a team to perform targeted influence mapping of KOLs via natural language processing.
    • Supervised all quality assurance pertaining to projects with art directors, copy editors, account executives, research analysts, and programmers to ensure the medical accuracy and medical strategy direction of client’s brand.

     

  • Post-Doctoral Fellow

    sanofi-aventis 2006 - 2007

     

    • Lead a cross-departmental team and an outside contractor to create a prototype corporate metabolism database.
    • Managed all aspects of the metabolism database starting with the design all the way through to the presentation of the corporate database to Global Department heads.
    • Successfully delivered the project on time and under budget.
    • Formulated and tested strategies to predict cytochrome P450 metabolic sites of potential drugs by evaluating the strengths and limitations of MetaSite. Propensity of metabolism for certain functional groups were also tabulated and ranked.
    • Explored the use of different docking programs to generate reasonable conformations to be used for MetaSite in hopes of increasing accuracy of predictions.Devised a scientific strategy to efficiently share metabolism data quickly between departments.

Publications

Lengyel, I.; Taldone, T.; Lyons, T.M.; Cesare, V.O. "Full Characterization, Thermal Decomposition, and Reactions of 1-(2-adamantyl)-3-(1-adamantyl)aziridin-2-one." Accepted by the Journal of Heterocyclic Chemistry

Barreiro, G.; Guimaraes, C. R. W.; Tubert-Brohman, I.; Lyons, T. M.; Tirado-Rives, J.; Jorgensen, W. L. "Search for Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase Using Chemical Similarity, Molecular Docking, and MM-GB/SA Scoring." J. Chem. Inf. Model. 47, 2416-2428 (2007)

Cesare, V.O.; Lyons, T.M.; Lengyel, I. "A High-Yielding Synthesis of a-Lactams (Aziridinones)." Synthesis, 12, 1716-1720 (2002).

Selected Presentations

T.M. Lyons, I. Tubert-Brohman, and W.L. Jorgensen “A Priori pKa predictions: Investigation of steric effects on the basicity of substituted pyridines via MC/FEP calculations” National ACS Meeting, New York, NY September 2003.

T.M. Lyons, I. Tubert-Brohman, and W.L. Jorgensen “A Priori pKa calculations and the Steric Effect on a Series of Substituted Pyridine Molecule” Yale University Biophysical Symposium, New Haven, CT May 2003

T.M. Lyons, V.O. Cesare, and I. Lengyel "A New Synthesis of a-Lactams (aziridinones).” National ACS Meeting Orlando, FL April 2002

T.M. Lyons and Carol Parish "Docking Studies Using the Low Mode Conformational Search Algorithm” National ACS Meeting San Francisco, CA March 2000

T.M. Lyons "Conformational Analysis of FDA Approved HIV Protease Inhibitors” Hobart and William Smith Colleges chapter Phi Beta Kappa Student Showcase Invited Talk Geneva, NY May 1999

T.M. Lyons and Carol Parish "Conformational Comparison of FDA Approved HIV Protease Inhibitors” National ACS Meeting Boston, MA August 1998.

Grants

NIH Biophysical Training Grant Recipient 2004 - 2005

Frederick W. Heyl Fellowship and Teaching Fellowship 2003 – 2004

Yale University and Teaching Fellowship 2002 - 2003

St. John's University Graduate Assistantship 2000 - 2002

Council on Undergraduate Research Summer Research Fellowship Summer 1999

Hobart and William Smith Colleges Provost Summer Fellowship Summer 1998

Teaching Experience

Spring 2004 Advanced Organic Chemistry - Yale University

Fall 2003 Organic Chemistry - Yale University

Spring 2003 and Fall 2002 General Chemistry Laboratory - Yale University

Spring 2002 Organic Chemistry Laboratory - St. John's University

Fall 2002 Organic Chemistry Laboratory - St. John's University

Spring 2001 Organic Chemistry Laboratory and General Chemistry Laboratory - St. John's University

Fall 2000 Organic Chemistry Laboratory and General Chemistry Laboratory - St. John's University

 
©2004 - 2011 Theresa M. Lyons. For questions or comments e-mail theresaattheresamlyons.com